Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC062
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-10-11 17:23
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 5 individuals with a value less than 0.52 were subsequently diagnosed with PD. That is, 11.9% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.52 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 25, 'TN': 21, 'TP': 17, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 3, 'TN': 4, 'TP': 39, 'FP': 26}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 33, 'TN': 28, 'TP': 9, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 7, 'TN': 5, 'TP': 35, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 15.004
timePerCircleCoV 0.515592
timePerCircleSlope -0.105814
meanError 1.40359
tremorFreq 5.27344
tremorRelPower 22.5685
tremorGyroAmpMean 0.0153061
tremorGyroAmpSlope 0.00431688
tremorGyroAmpCoV 0.530456
tremorCoordAmpMean 0.0385662
tremorCoordAmpSlope 0.00446761
tremorCoordAmpCoV 0.389295
tremorAccAmpMean 0.0309758
tremorAccAmpSlope 0.00425438
tremorAccAmpCoV 0.489802
tremorPcRelVar 0.664016
tremorPcX 0.410411
tremorPcY 0.911901

Circle Segment 1

Duration 36.56 s, Accuracy Estimate 1.136 (lower is better)

Circle Segment 2

Duration 14.76 s, Accuracy Estimate 1.212 (lower is better)

Circle Segment 3

Duration 11.36 s, Accuracy Estimate 1.382 (lower is better)

Circle Segment 4

Duration 12.96 s, Accuracy Estimate 0.982 (lower is better)

Circle Segment 5

Duration 14.8 s, Accuracy Estimate 1.036 (lower is better)

Circle Segment 6

Duration 14.36 s, Accuracy Estimate 1.979 (lower is better)

Circle Segment 7

Duration 11.84 s, Accuracy Estimate 1.319 (lower is better)

Circle Segment 8

Duration 11.76 s, Accuracy Estimate 1.33 (lower is better)

Circle Segment 9

Duration 11.28 s, Accuracy Estimate 1.62 (lower is better)

Circle Segment 10

Duration 10.36 s, Accuracy Estimate 2.039 (lower is better)

Spiral

numSpirals 9
timePerSpiralMean 27.8
timePerSpiralCoV 0.294848
timePerSpiralSlope -0.0718945
meanError 2.15721
tremorFreq 5.85938
tremorRelPower 29.8451
tremorGyroAmpMean 0.0120897
tremorGyroAmpSlope 0.000184634
tremorGyroAmpCoV 0.514358
tremorCoordAmpMean 0.0524496
tremorCoordAmpSlope 0.00463889
tremorCoordAmpCoV 0.859223
tremorAccAmpMean 0.0508545
tremorAccAmpSlope -0.000105751
tremorAccAmpCoV 0.221503
tremorPcRelVar 0.655693
tremorPcX -0.588675
tremorPcY 0.80837

Spiral Segment 1

Duration 36.4 s, Accuracy Estimate 2.009 (lower is better)

Spiral Segment 2

Duration 32.84 s, Accuracy Estimate 1.67 (lower is better)

Spiral Segment 3

Duration 31.16 s, Accuracy Estimate 1.998 (lower is better)

Spiral Segment 4

Duration 28.16 s, Accuracy Estimate 1.812 (lower is better)

Spiral Segment 5

Duration 23.04 s, Accuracy Estimate 1.959 (lower is better)

Spiral Segment 6

Duration 41.16 s, Accuracy Estimate 1.597 (lower is better)

Spiral Segment 7

Duration 18.36 s, Accuracy Estimate 2.199 (lower is better)

Spiral Segment 8

Duration 19.52 s, Accuracy Estimate 2.179 (lower is better)

Spiral Segment 9

Duration 19.56 s, Accuracy Estimate 3.992 (lower is better)

Elel

eDurationMean 0.555851
eDurationStd 0.251758
eDurationStdnorm 0.452923
eDurationMedian 0.485
eDurationQuartdelta 0.27625
eDurationQuartdeltanorm 0.569588
eDurationKurt 5.87017
eDurationTrenddiff -0.16
eDurationTrendratio 0.739837
eWidthMean 5.99189
eWidthStd 2.24841
eWidthStdnorm 0.375243
eWidthMedian 5.616
eWidthQuartdelta 2.95425
eWidthQuartdeltanorm 0.526042
eWidthKurt 5.36045
eWidthTrenddiff 1.287
eWidthTrendratio 1.2619
eHeightMean 6.95279
eHeightStd 2.40865
eHeightStdnorm 0.34643
eHeightMedian 6.786
eHeightQuartdelta 2.6325
eHeightQuartdeltanorm 0.387931
eHeightKurt 3.13777
eHeightTrenddiff -0.702
eHeightTrendratio 0.9
eAspectMean 0.921494
eAspectStd 0.392368
eAspectStdnorm 0.425795
eAspectMedian 0.822581
eAspectQuartdelta 0.440778
eAspectQuartdeltanorm 0.535848
eAspectKurt 5.82312
eAspectTrenddiff 0.256515
eAspectTrendratio 1.35475
eSlantMean 0.0921303
eSlantStd 0.367765
eSlantStdnorm 3.99179
eSlantMedian 0.104167
eSlantQuartdelta 0.425343
eSlantQuartdeltanorm 4.08329
eSlantKurt 5.10936
eSlantTrenddiff 0.1
eRtopMean 0.661365
eRtopStd 0.180982
eRtopStdnorm 0.273649
eRtopMedian 0.666667
eRtopQuartdelta 0.295404
eRtopQuartdeltanorm 0.443106
eRtopKurt 2.42799
eRtopTrenddiff 0.0218579
eRbotMean 0.592054
eRbotStd 0.311234
eRbotStdnorm 0.525685
eRbotMedian 0.516667
eRbotQuartdelta 0.376079
eRbotQuartdeltanorm 0.727894
eRbotKurt 3.78071
eRbotTrenddiff -0.0833333
eRrightMean 0.730804
eRrightStd 0.175974
eRrightStdnorm 0.240794
eRrightMedian 0.785714
eRrightQuartdelta 0.191385
eRrightQuartdeltanorm 0.243581
eRrightKurt 2.63674
eRrightTrenddiff -0.0198413
eRleftMean 0.381444
eRleftStd 0.147711
eRleftStdnorm 0.387241
eRleftMedian 0.357143
eRleftQuartdelta 0.248973
eRleftQuartdeltanorm 0.697123
eRleftKurt 2.27767
eRleftTrenddiff -0.0315315
lDurationMean 0.891786
lDurationStd 0.37138
lDurationStdnorm 0.416445
lDurationMedian 0.7975
lDurationQuartdelta 0.27
lDurationQuartdeltanorm 0.338558
lDurationKurt 6.51715
lDurationTrenddiff -0.175
lDurationTrendratio 0.803371
lWidthMean 8.88364
lWidthStd 2.99492
lWidthStdnorm 0.337128
lWidthMedian 8.8335
lWidthQuartdelta 4.095
lWidthQuartdeltanorm 0.463576
lWidthKurt 3.39894
lWidthTrenddiff 2.574
lWidthTrendratio 1.35484
lHeightMean 19.9011
lHeightStd 3.71246
lHeightStdnorm 0.186545
lHeightMedian 19.656
lHeightQuartdelta 6.084
lHeightQuartdeltanorm 0.309524
lHeightKurt 2.30828
lHeightTrenddiff 4.563
lHeightTrendratio 1.26174
lAspectMean 0.455544
lAspectStd 0.151861
lAspectStdnorm 0.333362
lAspectMedian 0.455931
lAspectQuartdelta 0.232184
lAspectQuartdeltanorm 0.509252
lAspectKurt 2.49322
lAspectTrenddiff 0.0628116
lAspectTrendratio 1.15254
lSlantMean 0.146433
lSlantStd 0.181519
lSlantStdnorm 1.23961
lSlantMedian 0.134495
lSlantQuartdelta 0.29002
lSlantQuartdeltanorm 2.15636
lSlantKurt 2.20155
lSlantTrenddiff 0.0697222
lRtopMean 0.745114
lRtopStd 0.150967
lRtopStdnorm 0.202609
lRtopMedian 0.771237
lRtopQuartdelta 0.190901
lRtopQuartdeltanorm 0.247526
lRtopKurt 3.05632
lRtopTrenddiff -0.00976426
lRbotMean 0.51855
lRbotStd 0.291984
lRbotStdnorm 0.563078
lRbotMedian 0.442912
lRbotQuartdelta 0.338099
lRbotQuartdeltanorm 0.763356
lRbotKurt 4.3691
lRbotTrenddiff -0.127609
lRrightMean 0.841128
lRrightStd 0.085658
lRrightStdnorm 0.101837
lRrightMedian 0.847914
lRrightQuartdelta 0.129937
lRrightQuartdeltanorm 0.153243
lRrightKurt 3.01924
lRrightTrenddiff -0.0156573
lRleftMean 0.266418
lRleftStd 0.199406
lRleftStdnorm 0.748472
lRleftMedian 0.197938
lRleftQuartdelta 0.139263
lRleftQuartdeltanorm 0.70357
lRleftKurt 5.18229
lRleftTrenddiff -0.0629371

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.877939
sumTouchScores 25.4602
meanMovementTime 0.64125
numTouches 29
undershootPercentage 0
overshootPercentage 10.3448

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.857495
sumTouchScores 15.4349
meanMovementTime 1.00824
numTouches 18
undershootPercentage 5.55556
overshootPercentage 5.55556

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 22.744
timePerZigzagCoV 0.0758755
timePerZigzagSlope -0.0233908
meanError 2.11737
tremorFreq 5.95703
tremorRelPower 29.402
tremorGyroAmpMean 0.0114023
tremorGyroAmpSlope -0.00113792
tremorGyroAmpCoV 0.3144
tremorCoordAmpMean 0.157784
tremorCoordAmpSlope 0.00421982
tremorCoordAmpCoV 1.11611
tremorAccAmpMean 0.0389661
tremorAccAmpSlope 0.00141629
tremorAccAmpCoV 0.39637
tremorPcRelVar 0.850326
tremorPcX -0.0634073
tremorPcY 0.997988

ZigZag Segment 1

Duration 23.92 s, Accuracy Estimate 1.945 (lower is better)

ZigZag Segment 2

Duration 21.6 s, Accuracy Estimate 1.983 (lower is better)

ZigZag Segment 3

Duration 25.16 s, Accuracy Estimate 1.935 (lower is better)

ZigZag Segment 4

Duration 21.96 s, Accuracy Estimate 2.435 (lower is better)

ZigZag Segment 5

Duration 21.08 s, Accuracy Estimate 2.288 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 19.72
timePerZigzagCoV 0.133505
timePerZigzagSlope -0.0551724
zigzagHeightMean 60.5474
zigzagHeightCoV 0.0926932
zigzagHeightSlope -0.0539101
meanError 0.0442713
tremorFreq 6.15234
tremorRelPower 25.4759
tremorGyroAmpMean 0.0142962
tremorGyroAmpSlope -7.00647e-05
tremorGyroAmpCoV 0.46635
tremorCoordAmpMean 0.12833
tremorCoordAmpSlope 0.00215862
tremorCoordAmpCoV 1.07148
tremorAccAmpMean 0.0759846
tremorAccAmpSlope -0.000745102
tremorAccAmpCoV 0.117555
tremorPcRelVar 0.874134
tremorPcX -0.201166
tremorPcY 0.979557

ZigZag Offset Segment 1

Duration 20.04 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 2

Duration 23.64 s, Accuracy Estimate 0.028 (lower is better)

ZigZag Offset Segment 3

Duration 18.52 s, Accuracy Estimate 0.059 (lower is better)

ZigZag Offset Segment 4

Duration 19.96 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 5

Duration 16.44 s, Accuracy Estimate 0.069 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.57}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.52}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.05395137390908866}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8975267663577082}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}